One of the situations was the one involving Harry and Tyrone. They devise a scheme that will bring them great profits. It involves buying heroin at a lower price and then selling it on the street for a higher price. It actually worked for a while, but eventually things went south. When the salesman, Brode, who was supplying, was about to promote Tyrone to a higher and better paid dealer, Brode was murdered by Sal the Geep, who was his competitor. Tyrone was arrested and they spent the money raised from the drug dealing on his bail. They never got the money back and things continued to go downhill from there. They try to recoup the money by traveling to Florida to buy heroin, but by this point Harry's infected arm is on the verge of no return and is eventually amputated due to gangrene. Both Tyrone and Harry are arrested and the story with them ends there. It is clear that both of them found themselves in this situation. There is absolutely no fate to be seen in this. At all times they managed to prevent all this from happening. The paths they chose took them there, and that's still the case today