Introduction: Throughout history there are many examples of humans conducting experiments on other humans. Over the years, human experimentation has greatly advanced knowledge of human physiology and psychology, leading to better treatments for both physical and mental ailments, as well as a better overall understanding of the human constitution. For all the good that human experimentation has done for the human race, there have been times when experimenters have taken human experimentation beyond the bounds of morality. This unethical human experimentation is most often caused when experimenters are, somehow, unable to justify their experiments. What is unethical human experimentation? Unethical human experimentation can be defined as experimentation on a human subject in which the subject is an unwilling participant and/or the subject of the experiment is subjected to unnecessary pain or discomfort, whether physical, mental, or emotional. Historical instances of Unethical human experimentation: Although many of the most horrific examples of unethical human experimentation have occurred during times of war, unethical human experimentation has also occurred in times of peace. Some of the first recorded cases of unethical human experimentation occurred in the 1700s, when doctors tested vaccines on their slaves, often without informing them of the dangers involved. Edward Jenner, who was a pioneer in inoculation against smallpox and was called the "father of immunology", tested smallpox vaccines on nearby children and even on his own son. In his most famous experiment he injected an eight-year-old boy with pus scraped from the blisters of a cowpox-infected milkmaid and then later two different... middle of paper... hours or were stripped of their clothes and forced to Withstand temperatures up to 21 degrees for hours. In another German experiment, subjects were placed in a low-pressure chamber that simulated conditions at altitudes up to 66,000 feet. Justifications: There are three main justifications that people use when conducting unethical human experimentation: they are simply following orders, the experimental subjects are inferior, or that it is war. Conclusion: A lot of good came out as a result of human experimentation. Through dissecting cadavers we are able to learn a lot about how the body works, and through drug testing we are able to find cures and treatments for diseases. However, throughout history there have been many incidents where human experimentation has overstepped the bounds of morality and resulted in horrific atrocities..