The position of the affected kidneys can also be a source of pain. The kidneys are located on both sides of the body, directly under the diaphragm, near the lower back, which is why the pain can radiate to the abdominal sides of the lower back or even the legs. If the kidneys develop cysts due to polycystic kidney disease, this can understandably also cause pain in the lower back and legs. The kidneys produce urine to filter waste from the body. This means that often, when the kidneys are compromised, urinary urgency may occur frequently in the middle of the night and you may notice that you have to urinate more often with greater pressure and in larger quantities. The pressure on your bladder may be so strong that you can't pass all the urine out when you go to the bathroom (similar to a urinary tract infection). If your urine contains blood, you should seek medical attention immediately. Fatigue is a symptom of kidney failure, healthy kidneys produce adequate amounts of EPO (erythropoietin) hormones which control