Severe sepsis is linked to systemic inflammatory response (SIRS) symptoms characterized by widespread increases in reactive air species (ROS) and increased circulating amounts of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6). The development of SIRS is certainly one of the main factors triggering the symptoms of multiorgan dysfunction (MODS) and death in septic subjects [1,2]. Although the SIRS response can be elicited by mycobacteria, organisms, fungal infections, and infections, exposure to gram-negative bacteria and lipopolysaccharides (LPS) is definitely believed to be the predominant trigger [3,4]. Among the various organ systems affected by sepsis, the liver is found to be one of the first organs affected as liver organ macrophages (Kupffer cells) have been shown to play an essential role in the removal of xenobiotics from the bloodstream [5]. It is well known that LPS excitation of Kupffer cells results in the release of several cytokines/chemokines including TNF-α, IL-6, HMGB1, and nitric oxide (NO) [6], which have been shown to stimulate development of SIRS. We say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Factors that regulate the release of cytokines from macrophages are not entirely clear, although it has been hypothesized that this process is controlled, at least in part, by increases in cellular ROS which has led some to hypothesize that the use of antioxidants may be valuable for the treatment of sepsis [9-11]. Although effective in pets, most interventional research examining the outcomes of antioxidant treatments has been largely ineffective in clinical trials [12]. The factors for these failures are currently unknown and most likely of a complicated nature, but may be related to the fact that treatment of sepsis is often hampered by sepsis-associated circulatory abnormalities, poor biodistribution, and specific variations in septic manifestation. . Furthermore, the use of traditional medicinal methods may be limited by the need for multiple daily dosages since each antioxidant molecule is generally capable of eliminating only one major free drug [13]. In an effort to overcome these restrictions, we wanted to develop a treatment that would not only focus on the liver organ's Kupffer cells responsible for initiating the progression of SIRS, but would also be able to show continuous activity over time. Curcumin is organic phytochemicals and organic polyphenolic substance which is prepared from the primary curcuminoid of turmeric (Curcuma longa) mainly used as a natural component of makeup, food flavoring, dietary supplement and food coloring. Additionally, curcumin offerings have received considerable attention in cancer prevention, tumor therapy, and the prevention or treatment of major age-related disabling neurodegenerative diseases, as demonstrated by cell culture and pet size data [16 -18]. Although the medical efficacy of curcumin is still significantly hindered, due to its low water solubility, chemical instability (hydrolytic degradation at pH > 7.0) and poor dental bioavailability [19,20], but Curcumin has demonstrated many pharmacological actions in the preclinical procedure, including anticancer, antioxidant, anti-inflammatory, antimicrobial, anti-HIV [21-25], and antidepressant. So far, the combination of curcumin with many molecular focuses on receptors such as developmental elements, digestive enzymes, cytokines, hypoacetylation of.